Dr. Cascio was born and raised in New Orleans, Louisiana. He attended Duke University, where he majored in History and Biology and played club football and baseball. He graduated from Louisiana State University Medical School in New Orleans with Honors, where he was president of Alpha Omega Alpha. Dr. Cascio completed his orthopaedic surgery residency at The Johns Hopkins Hospital, where he was named Administrative Chief Resident. Dr. Cascio is a Captain in the U.S. Army Reserves.
Dr. Cascio's two main areas of research are cartilage regeneration and the medicolegal aspects of compartment syndrome. Dr. Cascio has presented his research at several national meetings, including the American Academy of Orthopaedic Surgeons and the International Cartilage Repair Society, and has published his work, in journals such as the Journal of Bone and Joint Surgery and Clinical Orthopaedics and Related Research.